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目的 观察重组人类表皮生长因子 (rh EGF)滴眼液对超声乳化白内障术后泪膜的疗效。方法 随机选择两组超声乳化白内障术后患者 ,A组 (74只眼 )术后给予 rh EGF眼液 ;B组 (87只眼 )术后给予赋形剂。分别于术后第 1天、7天、15天、30天进行干眼症状、角膜荧光素染色、泪膜破裂时间 (BU T)及泪液分泌试验观察加以比较 ,并进行统计学分析。结果 术后第 7天两组患者的干眼症状、BU T、泪液分泌量及角膜荧光素着色均有好转 (P<0 .0 1) ,两组间差异无显著性 (P>0 .0 5 ) ;而术后第 15天、30天 A组各项检查结果均有反复 ,与术后第 1天比较差异无显著性 (P>0 .0 5 ) ,B组各项检查结果反复较小 ,与术后第 1天比较 ,差异有显著性 (P<0 .0 5 )。结论 rh EGF滴眼液对超声乳化白内障术后泪膜的修复有促进作用。
Objective To observe the effect of recombinant human epidermal growth factor (rh EGF) eye drops on tear film after phacoemulsification. Methods Two groups of patients were selected randomly after phacoemulsification. Group A (74 eyes) were given rh EGF eyelid postoperatively. Group B (87 eyes) were given excipients after operation. The symptoms of dry eye, corneal fluorescein staining, tear burst time (BU T) and tear secretion test were compared on the 1st day, 7th day, 15th day and 30th day respectively after operation and statistically analyzed. Results On the 7th day after operation, the symptoms of dry eye, BU T, tear volume and corneal fluorescein staining were all improved in both groups (P <0.01), with no significant difference between the two groups (P> 0.05) 5). On the 15th day and the 30th day after operation, all the test results in group A were repeated, which showed no significant difference compared with the first day after operation (P> 0.05). The test results in group B were repeated Small, compared with the first day after operation, the difference was significant (P <0. 05). Conclusion rh EGF eye drops can promote the repair of tear film after phacoemulsification.