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目的 :了解 2型糖尿病 (2DM )患者的诱发电位 (EP) ,包括视觉 (VEP)、脑干听觉 (BAEP)、体感 (SEP)和事件相关电位 (ERP)的表现。方法 :用NicoletVikingTV型肌电图 /诱发电位仪对 3 0例 2DM病人 (DM组 )及 3 0例正常人 (对照组 )进行VEP、BAEP、SEP、ERP检测。比较两组间EP各项参数的差异。结果 :DM组VEP异常 2 0例(66 7% ) ,BAEP异常 18例 (60 % ) ,上肢正中神经SEP(MNSEP)及下肢胫后神经SEP(PTNSEP)异常分别为 2 0例(66 7% )和 2 2例 (73 3 % ) ,ERP异常 11例 (3 6 7% ) ,表现为波形缺失、波潜伏期 (PL)延长及波幅 (Amp)下降。DM组VEPP10 0 的PL ,BAEP中Ⅰ波PL ,Ⅴ波PL及Amp和各波间期 (IPL) ,MNSEP中N9～P2 0 ,PTNSEP中N9～P3 8的PL及Amp、ERP中N2 、P3 的PL及Amp异常与对照组比较差异均有显著意义 (P <0 0 5或P <0 0 0 1)。结论 :DM患者VEP、BAEP、SEP、ERP都有不同程度异常 ,EP是检测DM神经病变的敏感指标。
Objectives: To investigate the evoked potentials (EPs) in patients with type 2 diabetes mellitus (DM), including visual (VEP), brainstem auditory (BAEP), somatosensory (SEP) and event related potentials (ERP). Methods: VEP, BAEP, SEP and ERP were detected in 30 DM patients and 30 healthy controls (control group) with NicoletViking TV electromyography / evoked potentiometer. Differences in EP parameters between the two groups were compared. Results: 20 cases (66.7%) had abnormal VEP in DM group, 18 cases (60%) had abnormal BAEP, 20 cases (66.7%) in abnormal SEP (MNSEP) and posterior tibial nerve (PTNSEP) ) And 22 cases (73.3%). Eleven patients had abnormal ERP (36.7%), showing waveform loss, prolongation of wave latency (PL) and decrease of amplitude (Amp). PL, BAEP wave PL and Amp wave and each wave interval (IPL), N9 ~ P2 0 in MNSEP, PL and Amp of N9 ~ P3 8 in PTNSEP, N2, P3 in ERP The PL and Amp abnormalities were significantly different from the control group (P <0.05 or P <0.01). Conclusion: VEP, BAEP, SEP and ERP in DM patients all have different degrees of abnormality. EP is a sensitive index to detect DM neuropathy.