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目的探讨莫西沙星治疗老年社区获得性肺炎患者的临床疗效。方法选取2012年6月至2014年6月辽宁省锦州市第二医院收治的60例老年社区获得性肺炎患者为研究对象,按照随机数字表法分为对照组与观察组,每组30例。在常规治疗的基础上,对照组患者采用左氧氟沙星治疗,400 mg/次,1次/d;观察组采用莫西沙星治疗,治疗初期采用静脉给药,400 mg/d,1次/d,病情缓解后改为口服,剂量不变。比较两组患者的治疗效果。结果治疗后观察组总有效率为93.3%,对照组总有效率为80.0%,两组差异有统计学意义(P<0.05)。观察组细菌清除率为93.3%,明显高于对照组的83.3%,差异有统计学意义(P<0.05)。两组患者不良反应均较轻微,可耐受,不影响治疗。结论莫西沙星对老年社区获得性肺炎具有良好的疗效,不良反应少。
Objective To investigate the clinical efficacy of moxifloxacin in the treatment of elderly community-acquired pneumonia. Methods Sixty elderly community-acquired pneumonia patients admitted to the Second Hospital of Jinzhou City, Liaoning Province from June 2012 to June 2014 were selected as study subjects and divided into control group and observation group according to the random number table method, with 30 cases in each group. On the basis of conventional treatment, patients in the control group were treated with levofloxacin 400 mg once daily, while those in the observation group were treated with moxifloxacin 400 mg once daily for the first time After remission to oral, the same dose. The treatment effect of two groups of patients was compared. Results After treatment, the total effective rate was 93.3% in the observation group and 80.0% in the control group, with significant difference between the two groups (P <0.05). The bacterial clearance in the observation group was 93.3%, which was significantly higher than that in the control group (83.3%) (P <0.05). Adverse reactions in both groups were mild, tolerable, does not affect the treatment. Conclusion Moxifloxacin has good curative effect on elderly community-acquired pneumonia with few adverse reactions.