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目的探讨硝苯地平联合硫酸镁治疗妊娠高血压孕妇的临床效果及安全性。方法选取2014年1-6月抚顺矿务局总医院收治的102例妊娠高血压孕妇为研究对象,按随机数字表法将其分为观察组和对照组,各51例。对照组孕妇给予硫酸镁,观察组孕妇在对照组基础上口服硝苯地平控释片,比较两组产妇治疗前后的血压变化、分娩方式、妊娠结局及并发症发生情况。结果治疗后,观察组孕妇的收缩压、舒张压均明显低于对照组,差异均有统计学意义(均P<0.05);观察组孕妇的自然分娩率明显高于对照组,差异有统计学意义(P<0.05);观察组孕妇宫缩乏力、产后出血、胎儿窘迫、新生儿窒息的发生率均明显低于对照组,差异均有统计学意义(均P<0.05)。结论硝苯地平联合硫酸镁治疗治疗妊娠高血压孕妇疗效确切,能有效降低血压及产后并发症发生率,提高自然分娩率。
Objective To investigate the clinical effect and safety of nifedipine combined with magnesium sulfate in the treatment of pregnant women with pregnancy-induced hypertension. Methods A total of 102 pregnant women with gestational hypertension admitted to the General Hospital of Fushun Mining from January to June 2014 were selected as study subjects, and divided into observation group and control group according to random number table method, with 51 cases in each group. Control group of pregnant women given magnesium sulfate, the observation group of pregnant women on the basis of the control group oral nifedipine controlled release tablets, compared two groups of maternal blood pressure before and after treatment, mode of delivery, pregnancy outcomes and complications. Results After treatment, systolic blood pressure and diastolic blood pressure of pregnant women in the observation group were significantly lower than those in the control group (all P <0.05). The rate of natural childbirth in the observation group was significantly higher than that of the control group (P <0.05). The incidence of uterine inertia, postpartum hemorrhage, fetal distress and neonatal asphyxia in the observation group were significantly lower than those in the control group (all P <0.05). Conclusion Nifedipine combined with magnesium sulfate treatment of pregnancy-induced hypertension in pregnant women with exact effect, can effectively reduce the incidence of post-natal complications of blood pressure and improve the rate of natural delivery.