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目的 探讨胃MALT增生的诊断、与Hp感染关系以及监测向胃MALT淋巴瘤的进展。方法 胃镜筛选对 31例有镜下特征表现病例进行组织学检查 ,同时用改良Giemsa染色查Hp、快速尿素酶试剂试验、组织学免疫组化染色 ,并对 31例慢性胃炎粘膜组织行免疫组化染色作对照 ,了解其淋巴细胞类型。 31例患者均接受正规抗Hp三联药物治疗。结果 胃MALT增生胃镜及组织学有特征表现 ,与Hp感染有关 ,增殖的淋巴细胞既有T细胞也有B细胞 ,周围血淋巴细胞亚群正常。结论 胃MALT增生是具有一定特征的胃病变 ,其发生与Hp感染有相关性 ,是一种胃局部慢性炎症引起的免疫反应性淋巴增生 ,因此需正规抗Hp治疗和长期内镜及组织学追踪检测有否向胃MALT淋巴瘤发展可能。
Objective To investigate the diagnosis of gastric MALT hyperplasia, the relationship with Hp infection and the monitoring of the progression to gastric MALT lymphoma. Methods Twenty-one patients with microscopic appearances were examined by gastroscopy. Hp was also detected by modified Giemsa staining, rapid urease test and histological immunohistochemical staining. Immunohistochemistry was performed on 31 chronic gastritis mucosal tissues Staining as a control to understand its lymphocyte type. All 31 patients received formal anti-Hp triple therapy. Results Gastric MALT hyperplasia gastroscopy and histological features, and Hp infection, proliferation of lymphocytes both T cells and B cells, peripheral blood lymphocyte subsets normal. Conclusions Gastric MALT hyperplasia is a gastric lesion with certain characteristics. It is associated with Hp infection and is an immunoreactive lymphoid hyperplasia caused by local chronic inflammation of the stomach. Therefore, it is necessary to treat with regular anti-Hp therapy and long-term endoscopic and histological follow-up Detection of gastric MALT lymphoma may develop.