论文部分内容阅读
目的评价多烯磷脂酰胆碱联合地衣芽孢杆菌治疗非酒精性脂肪性肝炎的临床疗效及安全性。方法选取永煤集团总医院2013年1月—2016年4月收治的71例非酒精性脂肪性肝炎患者,随机分为观察组(n=46)和对照组(n=25),两组患者均给予多烯磷脂酰胆碱治疗,观察组患者加用地衣芽孢杆菌治疗,3次/d,于三餐后温水口服。两组患者均治疗3个月,并给予饮食指导和运动指导。对比分析两组总有效率、肝功能相关指标、血脂指标、不良反应发生率的差异。采用SPSS18.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,计数资料用率(%)表示,采用χ2检验,P<0.05为差异有统计学意义。结果观察组总有效率为91.30%(42/46),对照组总有效率为68.00%(17/25),观察组治疗效果优于对照组,差异有统计学意义(P<0.05);观察组治疗后的丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、谷氨酰转肽酶(GGT)水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后血脂相关指标总胆固醇(TC)、甘油三酯(TG)水平低于对照组,差异有统计学意义(P<0.05);观察组1例发生腹泻,1例出现食欲减退,不良反应发生率为4.35%(2/46),对照组1例发生腹泻,不良反应发生率为4.00%(1/25),两组不良反应率比较差异无统计学意义(P>0.05)。结论多烯磷脂酰胆碱联合地衣芽孢杆菌治疗非酒精性脂肪性肝炎可减少脂质含量,改善患者的肝功能,显著缓解患者的症状,提高治疗效果,安全性高。
Objective To evaluate the clinical efficacy and safety of polyene phosphatidylcholine combined with Bacillus licheniformis in the treatment of non-alcoholic steatohepatitis. Methods A total of 71 non-alcoholic steatohepatitis patients admitted to the Yongmei Group General Hospital from January 2013 to April 2016 were randomly divided into observation group (n = 46) and control group (n = 25) Were given polyene phosphatidylcholine treatment, the observation group plus Bacillus licheniformis treatment, 3 times / d, after three meals of oral water. Two groups of patients were treated for 3 months, and give diet guidance and exercise guidance. The differences of total effective rate, liver function related index, blood lipid index and adverse reaction rate between the two groups were compared and analyzed. Statistical analysis was carried out by using SPSS18.0 statistical software. The measurement data were expressed as mean ± standard deviation (x ± s), t test was used and the count data was used (%), using χ2 test, P <0.05 was statistically significant significance. Results The total effective rate was 91.30% (42/46) in the observation group and 68.00% (17/25) in the control group. The treatment effect in the observation group was better than that in the control group (P <0.05) The levels of ALT, AST and GGT in the treatment group were lower than those in the control group (P <0.05). The levels of ALT, AST and GGT in the treatment group were significantly lower than those in the control group The levels of total cholesterol (TC) and triglyceride (TG) in the blood-lipid-related indicators of the patients after treatment were lower than those in the control group (P <0.05). One patient in the observation group had diarrhea and one patient had anorexia and adverse reactions The incidence of adverse reactions was 4.35% (2/46) in one case of the control group, and the incidence of adverse reactions was 4.00% (1/25). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Polyene phosphatidylcholine combined with Bacillus licheniformis treatment of non-alcoholic steatohepatitis can reduce the lipid content, improve the patient’s liver function, significantly alleviate the symptoms of patients and improve the treatment effect, high safety.