缺血缺氧性脑病是与围产期窒息密切相关的一种具严重后遗症的新生儿期疾病 ,它引起的脑瘫和智能落后影响了患儿终生的生存质量 ,尽管对其发病机制已逐渐明了 ,然而临床干预仍十分棘手。近年来国外学者研究发现 ,一些肽能生长因子 :如神经生长因子 (ＮＧＦ)、胰岛素样生长因子 1 Ischemic and hypoxic encephalopathy is a neonatal disease with severe sequelae, which is closely related to perinatal asphyxia. It causes cerebral palsy and mental retardation, which affects the life quality of children’s life span, although its pathogenesis has become clear However, clinical intervention is still very tricky. In recent years, foreign scholars found that some peptide growth factors: such as nerve growth factor (NGF), insulin-like growth factor 1