自1956年Bang等以革兰氏阴性细菌注入美州鲎后引起血管内凝血以来,鲎血细胞溶解物作为检测微量内毒素的方法广泛地应用于放射性药品、生物制品的热原(内毒素)检测和临床内毒素血症、菌尿症等的诊断,且较其它内毒素检测法灵敏、简便。为了解鲎血液对革兰氏阴性菌的内毒素的敏感性,探讨其血凝机制,本文仅就所见国外文献,以鲎血液凝固系统为中心,对鲎血内毒素凝集反应、凝血机制等,简要综述如下: 一、鲎血液凝血主要成份: 鲎是开放血管系统。血浆中含有血兰蛋白和磷脂酰胆碱,血细胞除含少量血兰蛋白的氰球(Cyanoblast)外,大部分是一 Since 1956, Bang and other Gram-negative bacteria injected into the state of the United States after the intravascular coagulation has been, hemolysis as a means of detection of trace endotoxin is widely used in radioactive drugs, biological products pyrogen (endotoxin) detection And clinical diagnosis of endotoxemia, bacteriuria, etc., and more sensitive than other endotoxin detection method, simple. In order to understand the sensitivity of blood to the endotoxin of Gram-negative bacteria and to explore the mechanism of blood coagulation, this paper focuses on the foreign literature, the blood coagulation system as the center, the agglutination of blood endotoxin, coagulation mechanism , A brief summary is as follows: First, 主 blood coagulation main components: 鲎 is open vasculature. Plasma contains porins and phosphatidylcholine, blood cells in addition to a small amount of hemagglutinin Cyanobacteria (Cyanoblast), the majority is a