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目的探讨放射性介入输卵管内注射氨甲蝶呤(MTX)在异位妊娠非手术治疗中的疗效及安全性。方法选取2010年1月～2011年12月期间在某院诊治的异位妊娠患者52例,均有保守治疗指证,随机分为观察组及对照组各26例,对照组采取氨甲喋呤肌肉注射保守治疗,观察组采取放射性介入输卵管内注射氨甲喋呤保守治疗。结果观察组治愈率92.31%(24/26),对照组治愈率69.23%(18/26),观察组用药后不良反应发生率7.69%(2/26),对照组不良反应发生率30.77%(8/26),血HCG恢复正常时间观察组为(12.20±8.84)d,对照组为(14.43±6.53)d,观察组平均住院时间为(9.82±2.13)d,住院费用(5310.00±539.50)元,对照组平均住院时间为(14.43±6.53)d,住院费用(2768.50±453.20)元,两组患者以上各项指标之间比较差异均有统计学意义(P﹤0.05)。结论输卵管异位妊娠采取放射性介入输卵管内注射MTX治疗安全,临床治愈率高。
Objective To investigate the efficacy and safety of radioactive interventional tubal injection of methotrexate (MTX) in non-surgical treatment of ectopic pregnancy. Methods 52 patients with ectopic pregnancy diagnosed and treated in a hospital from January 2010 to December 2011 were enrolled in this study. All patients were divided into observation group and control group with 26 cases in each group. The control group received methotrexate intramuscular injection conservative treatment , The observation group to take radioactive interventional tubal injection of methotrexate conservative treatment. Results The cure rate was 92.31% (24/26) in the observation group, 69.23% (18/26) in the control group, 7.69% (2/26) in the observation group and 30.77% in the control group The mean duration of hospitalization for HCG was (12.20 ± 8.84) days in the observation group and (14.43 ± 6.53) days in the observation group, and 9.82 ± 2.13 days in the observation group (5310.00 ± 539.50) (14.43 ± 6.53) d, and the cost of hospitalization (2768.50 ± 453.20) Yuan in the control group. There was significant difference between the above two indexes in both groups (P <0.05). Conclusion Tubal ectopic pregnancy using radioactive intervention tubal injection of MTX safe, high clinical cure rate.