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为探讨NT - 3与局灶性脑缺血后大脑皮质神经元损伤修复的关系 ,采用免疫组织化学ABC法观察了脑缺血 1h后大鼠大脑皮质NT - 3的变化 .结果 :NT - 3样免疫阳性反应物主要分布于大脑皮质第 3,5层的神经元 .脑缺血 1h后 ,NT - 3在皮质神经元的表达明显减少 (P <0 0 5 ) .提示NT - 3可能通过不同于其它生长因子的调节方式参与脑缺血后大脑皮层神经细胞的损伤修复
To investigate the relationship between NT - 3 and neuronal damage after focal cerebral ischemia in rats, the changes of NT - 3 in the cerebral cortex were observed by immunohistochemistry ABC method.Results: NT - 3 The immunoreactive positive neurons were mainly located in the neurons in the third and fifth cerebral cortex.After ischemia for 1h, the expression of NT - 3 in cortical neurons decreased significantly (P <0.05), suggesting that NT - 3 may pass Different from other growth factors in the regulation of cerebral ischemia in cerebral cortex neuronal injury repair