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萘啶酸是众所周知的光敏剂,一些研究提示与其结构相关的第二代氟喹诺酮类抗生素亦具有光毒性。本文报告在体外以及临床双盲,对照试验检测诺氟沙星(NF)光敏性的结果。 作者用UVA进行五种体外实验:①白念珠菌试验,观察培养的念珠菌的生长在应用药物+UVA照射后是否受到抑制;②光溶血试验,观察药物+UVA照射对红细胞
Nalidixic acid is a well-known photosensitizer and some studies suggest that the second-generation fluoroquinolone antibiotics that are structurally related also have phototoxicity. This article reports the results of the photosensitization of norfloxacin (NF) detected in vitro and in double-blind, clinical trials. The author of UVA for five in vitro experiments: ① Candida albicans test to observe the growth of Candida cultured in the application of drugs + UVA irradiation was inhibited; ② light hemolysis test, the drug + UVA irradiation of red blood cells