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肾脏疾病发病后,病变常进行性恶化,最终发展为慢性肾功能衰竭。引起肾脏病变的急性损害何以不能消除,反而表现为进行性疤痕化,最终导致肾功能衰竭是人们所关注的中心问题。肾脏疾病进行性恶化基本特点是肾小管间质纤维化。纤维增生性病变的发生及发展牵涉到病因、恶化因素及介质。病因是指一些阻止起始损害得以治愈,从而形成疤痕化的因素。恶化因素是促发肾功能恶化的某些不利因素,消除或缓解这些因素后,肾功能恶化速率可减慢,蛋白尿及高血压是两大主要促发因素,减轻蛋白尿及/或降低高血压,肾脏病变的恶化速度则明显减慢。介质是指某些介导纤维增生的分子,诸如转化生长因子β_1(TGF-β_1)、血小板原生长因子(PDGF)及组织金属蛋白酶1抑制剂(TIMP-
After the onset of kidney disease, the disease often progressive deterioration, eventually developing chronic renal failure. Caused by the acute lesions of renal disease can not be eliminated, but showed progressive scarring, and ultimately lead to renal failure is a central issue of concern. Progressive deterioration of renal disease is characterized by tubulointerstitial fibrosis. The occurrence and development of fibro-proliferative lesions involve the etiology, exacerbating factors and media. Etiology refers to a number of factors that prevent the initial lesion from being cured and thus scarring. Deteriorating factors are some of the unfavorable factors that contribute to the worsening of renal function. After the elimination or alleviation of these factors, the rate of deterioration of renal function can be slowed down. Proteinuria and hypertension are two major triggers for reducing proteinuria and / or decreasing high Blood pressure, kidney disease, the deterioration rate was significantly slowed down. Media refers to certain molecules that mediate fibrogenesis, such as transforming growth factor beta 1 (TGF-beta 1), platelet primary growth factor (PDGF), and tissue inhibitor of metalloproteinase 1 (TIMP-