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本文研究卡托普利治疗７０例充血性心力衰竭并发无症状性室性心律失常（治疗组）和常规治疗６３例（对照组）的２４小时动态心电图、血管紧张素Ⅱ浓度和随访（２．２±０．６年）的情况。结果：①口服卡托普利１２．５ｍｇ后２小时血浆血管紧张素Ⅱ浓度明显降低（Ｐ＜０．０１）；②口眼卡托普利４周后，治疗组室性心律失常分级明显低于对照组（Ｐ＜０．０１）；③长期口眼卡托普利使复杂性室性心律失常及再次住院的发生率明显低于对照组（Ｐ＜０．０１），病死串及心源性猝死率亦低于对照组（Ｐ＜０．０５）。这提示卡托普利对充血性心力衰竭及其并发的无症状性室性心律失常有满意的疗效。
In this paper, captopril treatment of 70 patients with congestive heart failure complicated by asymptomatic ventricular arrhythmias (treatment group) and conventional treatment of 63 patients (control group) 24-hour ambulatory electrocardiogram, angiotensin Ⅱ concentration and follow-up (2. 2 ± 0.6 years). Results: ① After 2 hours of taking captopril 12.5mg, the concentration of plasma angiotensin Ⅱ was significantly decreased (P <0.01); ② After 4 weeks of captopril, the grade of ventricular arrhythmia in the treatment group was significantly lower (P <0.01). ③ Long-term oral captopril caused the incidence of complex ventricular arrhythmias and re-hospitalization significantly lower than that of the control group (P <0.01) The rate of sudden death was also lower than that of the control group (P <0.05). This suggests that captopril has a satisfactory effect on congestive heart failure and its associated asymptomatic ventricular arrhythmias.