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目的:观察通络止痹汤对预防大肠癌行奥沙利铂化疗方案患者神经毒性反应的临床效果。方法:临床纳入行奥沙利铂化疗方案的大肠癌患者70例,根据化疗期间有无服用通络止痹汤分为观察组与对照组。观察组给予通络止痹汤口服,对照组单纯进行化疗。观察两组患者神经毒性反应的发生率以及分级,同时比较两组患者化疗前后神经生长因子水平与周围神经功能情况。结果:观察组神经毒性反应发生率为31.43%显著低于对照组的71.43%(P<0.05);观察组化疗后24 h、7天神经生长因子(NGF)水平均显著高于对照组(P<0.05);观察组化疗后感觉神经传导速度感觉神经动作电位波幅均显著高于对照组(P<0.05)。结论:通络止痹汤具有预防大肠癌行奥沙利铂化疗方案患者神经毒性反应的作用,其作用机制与提高NGF水平有关。
Objective: To observe the clinical effect of Tongluo Zhubi Decoction in preventing the neurotoxic reaction of oxaliplatin chemotherapy in colorectal cancer patients. Methods: Seventy patients with colorectal cancer undergoing chemotherapy with oxaliplatin were randomly divided into observation group and control group according to the presence or absence of Tongluo Zhizhi Decoction during chemotherapy. The observation group was given Tongluobibi decoction orally, and the control group was treated with chemotherapy alone. The incidence and grade of neurotoxic reaction in both groups were observed. The levels of nerve growth factor and peripheral nerve function were compared between the two groups before and after chemotherapy. Results: The incidence of neurotoxic reaction in observation group was significantly lower than that in control group (31.43% vs 71.43%, P <0.05). The levels of nerve growth factor (NGF) in observation group at 24 and 7 days after treatment were significantly higher than those in control group <0.05). The sensory nerve conduction velocity amplitude of sensory nerve conduction in the observation group after chemotherapy was significantly higher than that of the control group (P <0.05). Conclusion: Tongluo Zhixi Decoction can prevent the neurotoxic reaction of oxaliplatin chemotherapy in colorectal cancer patients. The mechanism of action is related to the increase of NGF level.