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本研究用兔78只,分两部分进行实验。第一部分,观察黄连注射液对家兔白细胞致热原(1eucocytic pyrogen;LP)性发热的降热效应;39只兔分成四组;Ⅰ为LP组;Ⅱ为黄连+LP组;Ⅲ为黄连组,Ⅳ为对照组。Ⅰ组9只兔,Ⅱ～Ⅳ组各10只兔。第二部分,观察黄连注射液对发热家兔脑脊液中cAMP含量变化的影响。动物数与分组同第一部分。结果表明,LP+黄连组60分钟△T℃(0.70±0.12),TRI_4(3.37±0.07)明显低于LP组△T℃(1.11+0.11)、TRI_4(5.56±0.10),分别比较两组△T℃、TRI_4,其差异性均非常显著(P<0.01)。上述两组动物60分钟脑脊液中cAMP含量分别为0.76±0.08和1.29±0.13,统计学处理后差异性非常显著(P<0.01)。黄连组动物60分钟△T℃(0.04±0.10)与对照组△T℃(0.03±0.06)相比较,无统计学意义(P>0.05)。作者推论:黄连注射液降热作用的机制,很可能与抑制POAH区神经元cAMP的生成有关。
In this study, 78 rabbits were used to conduct experiments in two parts. In the first part, the effects of Huanglian injection on the fever of rabbit leucocyte pyrogeneous (LP) fever were observed. Thirty-nine rabbits were divided into four groups; I was the LP group; II was the Coptis + LP group; III was the Huanglian group. IV is the control group. Nine rabbits in group I and 10 rabbits in groups II-IV. In the second part, the effects of Huanglian injection on the cAMP level in cerebrospinal fluid of rabbits with fever were observed. The number of animals is grouped with the first part. The results showed that LP + Coptis group 60 minutes △T °C (0.70 ± 0.12), TRI_4 (3.37 ± 0.07) was significantly lower than the LP group △ T °C (1.11 +0.11), TRI_4 (5.56 ± 0.10), respectively, compared the two groups △ T The differences between °C and TRI_4 were very significant (P<0.01). The content of cAMP in CSF was 0.76±0.08 and 1.29±0.13 in the above two groups at 60 minutes, and the difference was statistically significant (P<0.01). The Coptis group animals had no statistical significance (P>0.05) compared with the control group △T°C (0.03±0.06) for 60 min △T°C (0.04±0.10). The authors deduced that the mechanism of the heat-reducing effect of Huanglian injection may be related to the inhibition of neuronal cAMP production in the POAH region.