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目的:探究拉曼光谱技术应用于卵巢癌研究的可能性。方法:收集卵巢癌患者血清及健康人血清各20例,用激光共聚焦显微拉曼光谱仪进行检测。结果:两组血清的平均拉曼光谱形态和谱峰基本相似,但在约1010、1158、1283、1520、1646、2307和2661cm-17个拉曼频移附近,卵巢癌患者血清的拉曼光谱谱峰强度明显低于健康对照组,而在其余大部分波段,卵巢癌患者血清的拉曼光谱强度均高于健康对照组。结论:拉曼光谱技术可以初步区分卵巢癌及健康人血清,值得进一步研究和探讨其临床应用价值。
Objective: To explore the possibility of using Raman spectroscopy in ovarian cancer research. Methods: 20 cases of ovarian cancer serum and healthy human serum were collected and detected by laser confocal microscopy Raman spectroscopy. Results: The average Raman spectra of the two groups of serum were similar to those of the other two groups. However, in the vicinity of Raman shifts of about 1010, 1158, 1283, 1520, 1646, 2307 and 2661 cm-17, The peak intensity of the peak was significantly lower than that of the healthy control group, while in most of the remaining bands, the Raman intensity of the serum of patients with ovarian cancer was higher than that of the healthy control group. Conclusion: Raman spectroscopy can differentiate the serum of ovarian cancer and healthy people initially, so it is worth to further study and explore its clinical value.