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目的:探讨上海地区汉族人群组织型纤溶酶原激活物基因(TPA)多态性与脑梗死的关系。方法:采用PCR及基因测序技术检测157例急性脑梗死患者及169例对照组TPA-7351位点的多态性。应用非条件Logistic回归模型,调整混杂因素后,分析各基因型与急性脑梗死发生的关系。结果:在急性脑梗死组C/C基因型、C/T基因型和T/T基因型者分别为0.42、0.45和0.13。对照组依次分别为0.44、0.47和0.09。经调整混杂因素后,与C/C基因型相比,T/T基因型发生急性脑梗死的危险性显著升高(P<0.05);分层分析发现T/T基因型主要与腔隙性脑梗死的发病风险有关(P<0.05)。结论:在上海地区汉族人群中,TPA-7351C/T基因多态性与腔隙性脑梗死发病有关。
Objective: To investigate the relationship between tissue-type plasminogen activator (TPA) polymorphism and cerebral infarction in Han nationality in Shanghai. Methods: Polymorphisms of TPA-7351 in 157 patients with acute cerebral infarction and 169 controls were detected by PCR and gene sequencing. Non-conditional Logistic regression model was used to analyze the relationship between genotypes and acute cerebral infarction after adjusting confounding factors. Results: The C / C genotype, C / T genotype and T / T genotype in acute cerebral infarction group were 0.42,0.45 and 0.13 respectively. Control group followed by 0.44,0.47 and 0.09. Compared with C / C genotype, T / T genotype had a significantly increased risk of acute cerebral infarction (P <0.05) after adjusted for confounding factors. Stratified analysis showed that T / T genotype was mainly associated with lacunar The incidence of cerebral infarction risk (P <0.05). Conclusion: In Shanghai Han population, TPA-7351C / T polymorphism is associated with the pathogenesis of lacunar infarction.