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前言氨基环醇类抗生素是一类含有一个被氨基和羟基所取代的环烷化合物,其中一些品种是人们早已熟知的、至今仍是临床上最常用的抗生素,像链霉素、大观素等所含的氨基环醇并不是2-脱氧链霉胺(简称2-DOS,下同),但当今含2-DOS的抗生素仍构成了临床应用的氨基环醇类抗生素的主要部分,包括庆大霉素、西索米星。N-乙基-西索米星、卡那霉素、妥布拉霉素,丁胺卡那霉素、新霉素、巴龙霉素、青紫霉素和核糖霉素等。
Introduction Aminocyclic alcohol antibiotics are a class of naphthenic compounds containing a substituted amino and hydroxyl groups, some of which are already well-known, is still the most commonly used antibiotics in clinical practice, such as streptomycin, The aminocyclitol contained is not 2-deoxystreptamine (2-DOS, hereinafter the same), but today’s 2-DOS containing antibiotics still constitute the major part of the clinically used aminocyclitol antibiotics, Su, sisomicin. N-ethyl-sisomicin, kanamycin, tobramycin, amikacin, neomycin, paromomycin, cyanin and ribostamycin.