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目的探讨组织多肽特异性抗原(TPS)、癌胚抗原(CEA)、鳞状细胞癌相关抗原(SCC-Ag)及细胞角蛋白19片段(CYFRA21-1)评估头颈部肿瘤(HNC)的应用价值。方法收集HNC患者338例和健康对照组62例血液标本。采用ELISA法检测血清TPS水平,采用电化学发光法检测血清CEA、CYFRA21-1、SCC-Ag水平。结果晚期(Ⅲ、Ⅳ期)肿瘤患者的四种肿瘤标记物阳性率均高于早中期(Ⅰ、Ⅱ期)患者(P<0.01)。TPS、SCC-Ag、CYFRA21-1水平在淋巴结转移个数分组中比较有统计学差异(P<0.01)。56例手术HNC患者肿瘤切除前后TPS水平比较有统计学差异(P<0.01)。46例早期(Ⅰ期)肿瘤患者血清TPS水平高于健康对照组(P<0.05)。结论TPS、CEA、SCC-Ag及CYFRA21-1是HNC非常敏感、有用的肿瘤标记物评估指标。
Objective To investigate the application of tissue polypeptide-specific antigen (TPS), carcinoembryonic antigen (CEA), squamous cell carcinoma associated antigen (SCC-Ag) and cytokeratin 19 fragment (CYFRA21-1) value. Methods Blood samples were collected from 338 HNC patients and 62 healthy controls. The level of serum TPS was detected by ELISA and the level of serum CEA, CYFRA21-1 and SCC-Ag was detected by electrochemiluminescence. Results The positive rates of the four tumor markers in patients with advanced stage Ⅲ and Ⅳ tumors were significantly higher than those in early stage (stage Ⅰ and Ⅱ) (P <0.01). The levels of TPS, SCC-Ag and CYFRA21-1 in the group of lymph node metastasis were significantly different (P <0.01). The TPS levels of 56 HNC patients before and after resection were significantly different (P <0.01). The serum TPS level of 46 patients with early stage (stage Ⅰ) cancer was higher than that of healthy control group (P0.05). Conclusion TPS, CEA, SCC-Ag and CYFRA21-1 are highly sensitive and useful indicators of HNC tumor markers.