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目的观察辛伐他丁对冠心病高血脂症患者血清脂质的影响。方法冠心病高血脂症病人５０例，均有血脂（ＴＣ、ＴＧ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ或４项中任何一项）异常。服用辛伐他丁，５～２０ｍｇ，每日１次，晚间顿服，疗程８周。服药前后晨起空腹查血脂以作自身对照。结果对高ＴＣ下降有效率达９１．５％，对高ＬＤＬ－Ｃ下降有效率达８２．５％，对高ＴＧ下降有效率达７６．２％，对低ＨＤＬ－Ｃ增高有效率为７２．２％。其中对ＴＣ、ＬＤＬ－Ｃ治疗８周有极显著意义（Ｐ＜０．０１），，对ＴＧ下降、ＨＤＬ－Ｃ升高８周后有显著意义（Ｐ＜０．０５）。治疗期间不良反应轻微。结论辛伐他丁可作为冠心病患者减少ＣＨＤ事件发病率及住院率的理想药物。
Objective To observe the effects of simvastatin on serum lipids in patients with coronary heart disease and hyperlipidemia. Methods Fifty patients with coronary heart disease and hyperlipidemia had abnormal blood lipid (TC, TG, HDL-C, LDL-C or any of 4 items). Take simvastatin, 5 ~ 20mg, 1 day, Dayton clothing, treatment for 8 weeks. Before and after taking the morning fasting blood lipids to check for their own control. Results The effective rate of high TC decreased 91.5%, high LDL-C decreased 82.5%, high TG decreased 76.2% and low HDL-C increased 72%. 2%. Among them, TC and LDL-C had extremely significant significance for 8 weeks (P <0.01), and there was significant difference between TG and HDL-C after 8 weeks (P <0.05). Adverse reactions during treatment mild. Conclusion Simvastatin can be used as an ideal medicine to reduce the incidence of CHD and hospitalization rate in patients with coronary heart disease.