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有报道妊娠妇女禁忌使用利福平。动物实验结果:妊娠老鼠从第1～12天,每天接受利福平150毫克/公斤,则胎鼠畸形的发病率增加,最常受累的是神经系统,90%发生脊椎裂,其次是无脑畸形。随着剂量的增加,前爪、后爪、椎体和胸骨的非骨化骨成份也有增加。妊娠家兔从第1～6天,每天给予利福平200毫克/公斤,则未见有发生畸形影响,但妊娠的鼷鼠从第5～15天,接受相同剂量,中胚叶器官畸形(腭裂)的发病率达19%,且随剂量增加而增加。以上资料表明,妊娠动物虽仅是在器官发生的危险时期给予大剂量利福平时才发生畸形,但对妊娠妇女使用剂福平,纵使是很低剂量,也是极不明智的。自从9年前介绍利福平以来,有人收集了妊娠期间接受利福平治疗的226例孕妇资料,发现流产22例、分娩形态正常婴儿179例、畸形婴儿9例(无脑畸形1、脑积水1、脑积水+肢体畸形1,一侧耳廓萎缩及无外听道1、各种肾输尿管异常1、指异常+挠骨发育不全+左足畸形+无肛门1,前臂及手发育不全1、手指发育不全1、一侧髋关节先天性脱位1)、
It is reported that pregnant women contraindicated the use of rifampicin. Animal test results: Pregnant mice from day 1 to day 12, receiving rifampicin 150 mg / kg, the incidence of fetal malformations increased, the most commonly involved in the nervous system, 90% of the occurrence of spinal fractures, followed by no brain deformity. As dosages increased, non-ossifying bone components also increased in the front paw, hind paw, vertebral body and sternum. Pregnant rabbits from day 1 to day 6, given rifampicin 200 mg / kg, no abnormalities have been seen, but pregnancy zok rats from the 5th to 15 days to receive the same dose, mesodermal organ malformations ( Cleft palate) incidence rate of 19%, and increased with increasing doses. The above data show that pregnancy animals only deformity when given high doses of rifampicin during the dangerous period of organ development. However, it is extremely unwise to use forskolin in pregnant women, even at very low doses. Since the introduction of rifampicin 9 years ago, 226 pregnant women receiving rifampicin during pregnancy were collected and found 22 cases of abortion, 179 cases of normal delivery and 9 cases of deformed infants (anencephaly 1, Water 1, hydrocephalus + limb deformity 1, auricle side atrophy and no external auditory canal 1, a variety of renal ureter abnormalities 1, refers to the abnormal + radial deformity + left foot deformity + anus 1, forearm and hand hypoplasia 1 , Finger hypoplasia 1, one side of the hip congenital dislocation 1),