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目的:分析爱泼斯坦-巴尔病毒(EBV)、人乳头状瘤病毒(HPV)感染和口咽鳞癌(OPC)预后的相关性。方法:选取汕头市中心医院明确诊断OPC手术切除的标本97例,通过原位杂交及聚合酶链式反应(PCR)-反向点杂交的方法检测对蜡块组织中EBV、HPV感染检修检测,观察检测的情况。结果:T1+T2分期患者中位生存期明显比T3+T4分期患者长,组间比较,差异具有统计学意义(P<0.05);HPV的感染阳性患者中位生存期明显比阴性患者长,组间比较,差异具有统计学意义(P<0.05)。结论:OPC组织中有一定程度EBV、HPV感染的情况,HPV分化程度高、阳性与临床分期较早患者预后效果比较好,而EBV的感染对于OPC没有明显判断的价值。
Objective: To analyze the correlation between Epstein-Barr virus (EBV), human papillomavirus (HPV) infection and the prognosis of oropharyngeal squamous cell carcinoma (OPC). Methods: Ninety-seven cases of OPC resected specimens were selected from Shantou Central Hospital. In situ hybridization and polymerase chain reaction-reverse dot blotting were used to detect EBV and HPV infection in paraffin blocks. Observe the test situation. Results: The median survival time of T1 + T2 stage patients was significantly longer than that of T3 + T4 stage patients (P <0.05). The median survival time of HPV positive patients was significantly longer than that of negative patients, The differences between the two groups were statistically significant (P <0.05). Conclusion: There is a certain degree of EBV and HPV infection in OPC tissue. The high degree of HPV differentiation and the positive prognosis in patients with positive clinical stage are better in OPC tissue. But EBV infection has no obvious value in judging OPC.