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目的:观察消栓肠溶胶囊对缺血性中风气虚血瘀型患者血液流变学和凝血功能的影晌。方法:缺血性中风气虚血瘀型患者80例随机分为观察组和对照组,各40例。对照组给予常规治疗,观察组在对照组治疗的基础上加用消栓肠溶胶囊,0.4 g/次,3次/d。两组患者均连续治疗30 d。于治疗前后评估神经功能缺损评分(MESSS),Bartbel指数量表(MBI),检测血流变学指标[全血黏度高切,中切,低切,血浆黏度,红细胞压积(HCT),纤维蛋白原(Fib),红细胞沉降率(ESR)],凝血指标[凝血酶原时间(PT),活化部分凝血酶时间(APTT),血小板聚集率(PAR)及D-二聚体]及疗效指标(梗死灶体积,MESSS评分及MBI)。结果:治疗前两组患者的血流变学指标(全血黏度高切,中切,低切,血浆黏度,HCT,Fib及ESR),凝血指标(全血黏度高切,中切,低切,血浆黏度,HCT,Fib及ESR)及疗效指标(梗死灶体积,MESSS评分及MBI)比较差异无统计学意义,具有可比性;治疗30 d后,观察组的总有效率高于对照组(P<0.05);观察组的血流变学、凝血及疗效指标均优于对照组(P<0.01,P<0.05);观察组未发现明显的不良反应。结论:消栓肠溶胶囊治疗缺血性中风安全有效,改善血流变学和抗凝血功能可能为其作用机制之一。
Objective: To observe the effect of Xiaoshuan enteric-coated capsules on the hemorheology and coagulation function of patients with ischemic stroke with deficiency of blood and blood stasis. Methods: Eighty patients with ischemic stroke with deficiency of blood and blood stasis were randomly divided into observation group and control group, 40 cases each. The control group was given routine treatment. The observation group was treated with the control group with Xiaoshang enteric-coated capsules, 0.4g / time, 3 times / d. Two groups of patients were treated for 30 days. Neurological deficit scores (MESSS) and Bartbel Index Scale (MBI) were assessed before and after treatment. Hemorheological parameters (whole blood viscosity, middle and low cut, plasma viscosity, hematocrit, (Fib), erythrocyte sedimentation rate (ESR), coagulation index (PT, APTT, PAR and D-dimer) (Infarct volume, MESSS score and MBI). Results: The indexes of hemorheology (whole blood viscosity high cut, middle cut, low cut, plasma viscosity, HCT, Fib and ESR), coagulation indexes (whole blood viscosity high cut, middle cut, low cut , Plasma viscosity, HCT, Fib and ESR), and curative effect index (infarct size, MESSS score and MBI) were not statistically significant and comparable. After 30 days of treatment, the total effective rate of the observation group was higher than that of the control group P <0.05). Hemorrheology, coagulation and curative effect indexes of the observation group were better than those of the control group (P <0.01, P <0.05). No obvious adverse reactions were observed in the observation group. Conclusion: Xiaoshuan enteric-coated capsules is safe and effective in the treatment of ischemic stroke, which may be one of its mechanisms.