Ｇ’ｏｔｈ及Ｅａｔｏｎ报道过氧化氢酶缺乏患者的糖尿病发病率升高。他们假设这种酶的缺乏可导致细胞内氧化应激升高从而最终导致细胞功能衰退。他们指出β细胞富含线立体 ,它或许是反应性氧类 (Ｒｅａｃ ｔｉｖｅＯｘｙｇｅｎＳｐｅｃｉｅｓ,ＲＯＳ)的来源之一 ,然而线粒体电 G’oth and Eaton reported an increased prevalence of diabetes in patients with catalase deficiency. They hypothesized that the lack of this enzyme would lead to an increase in intracellular oxidative stress that eventually led to a decline in cellular function. They point out that beta cells are atrophy-rich and may be one of the sources of Reactive Oxygen Species (ROS), whereas mitochondrial electricity