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目的:探讨HER-2在胃癌组织中的表达及其与临床病理特征和预后的关系。方法:用免疫组化法检测126例胃癌组织和30例正常胃黏膜组织中HER-2表达,并与病理参数及预后比较分析。结果:胃癌组织HER2表达阳性率为29.4%(37/126),正常胃黏膜组织中无HER-2表达,P<0.05;HER-2表达与病变部位、分化程度、年龄、肿瘤浸润深度、有无远处转移、有无淋巴结转移及预后等密切相关,P<0.05;而与性别、是否侵犯神经及是否侵犯脉管无关,P>0.05。结论:HER2表达与胃癌的生物学行为有一定的相关性,检测胃癌组织中HER2的表达对于胃癌的治疗及预后判断有一定指导意义。
Objective: To investigate the expression of HER-2 in gastric carcinoma and its relationship with clinicopathological features and prognosis. Methods: The expressions of HER-2 in 126 gastric cancer tissues and 30 normal gastric mucosa tissues were detected by immunohistochemistry and compared with the pathological parameters and prognosis. Results: The positive rate of HER2 expression in gastric cancer tissues was 29.4% (37/126), but there was no HER-2 expression in normal gastric mucosa tissues (P <0.05). The expression of HER-2 was correlated with the location of the lesions, the degree of differentiation, the age, No distant metastasis, with or without lymph node metastasis and prognosis are closely related, P <0.05; and gender, whether the invasion of nerves and invasion of the vessel has nothing to do, P> 0.05. Conclusion: The expression of HER2 is related to the biological behavior of gastric cancer. Detecting the expression of HER2 in gastric cancer has some guiding significance for the treatment and prognosis of gastric cancer.