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目的 探讨超声检查联合血清癌抗原125(CA125)、血清糖链抗原199(CA199)、血清癌胚抗原(CEA)检测对卵巢恶性肿瘤的诊断价值.方法 回顾性分析2015年11月至2017年12月铜川矿务局中心医院收治的140例卵巢肿瘤患者的临床资料,经病理确诊分为卵巢良性肿瘤92例及卵巢恶性肿瘤48例.采用IU22超声诊断仪进行超声检查,所有卵巢良恶性肿瘤患者均进行血清学CA125、CA199、CEA检测.比较超声单独检测或联合以上血清学指标检测对良恶性肿瘤的诊断ROC、灵敏度、特异度、准确度 卵巢良性肿瘤患者超声诊断符合率明显高于卵巢恶性肿瘤患者(P＜0.01).卵巢良性肿瘤患者血清CA125、CA199、CEA水平均明显低于卵巢恶性肿瘤患者(P＜0.05),Ⅰ～Ⅱ期患者血清CA125、CA199、CEA水平均显著低于Ⅲ～Ⅳ期患者(P＜0.05).血清CA125、CA199、CEA水平对卵巢恶性肿瘤诊断ROC曲线下面积分别为0.788、0.750、0.708,诊断分界点分别为50.61 U/ml、36.47 U/ml、4.32 ng/ml,血清因子三者联合诊断曲线下面积为0.832.超声和三种血清因子联合检测的灵敏度、特异度、准确度均高于单项指标检测和血清联合检测.结论超声联合血清CA125、CA199、CEA水平检测可提高卵巢良恶性肿瘤诊断的灵敏度、特异度和准确度,具有一定临床应用价值.“,”Objective To investigate the diagnostic values of ultrasonography combined with serum cancer antigen 125 (CA125),serum carbohydrate antigen 199 (CA199),serum carcinoembryonic antigen (CEA) in ovarian malignant tumors.Methods From November 2015 to December 2017,140 patients with ovarian cancer admitted to the hospital were selected as subjects,and ultrasound examination was carried out with IU22 ultrasound diagnostic instrument.The patients were divided into 92 cases of benign ovarian tumors and 4-8 cases of malignant ovarian tumors through pathological diagnosis.The serum CA125,CA199 and CEA of all patients were detected by automatic biochemical analyzer,and receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of four combined detection in ovarian malignancies.Results The coincidence rate of ultrasound diagnosis in ovarian benign tumor patients was significantly higher than that in ovarian cancer patients (P ＜ 0.05).The levels of serum CA125,CA199 and CEA in benign ovarian tumors were significantly lower than those in malignant ovarian tumors (P ＜0.05),and the levels of serum CA125,CA199 and CEA in patients with stage Ⅰ to Ⅱ were significantly lower than those in stage Ⅲ to Ⅳ (P ＜ 0.05).The area of serum CA125,CA199 and CEA under the ROC curve was 0.788,0.750 and 0.708,respectively.The boundary points of diagnosis were 50.61 U/ml,36.47 U/ml and 4.32 ng/ml,respectively.The area under the combined diagnosis curve of the serum CA125,CA199 and CEA was 0.832.The sensitivity,specificity and accuracy of the combined detection were higher than that of single index detection and serum combined detection.Conclusions Ultrasound combined with serum CA125,CA199 and CEA levels detection can improve the sensitivity,specificity and accuracy of diagnosis of ovarian benign and malignant tumors,which has certain clinical value.