有关NK细胞调节的研究已有很大进展,但对其起源及其在干细胞水平上调节的认识还很缺乏。已知NK细胞起源于骨髓细胞并高度依赖于骨髓功能。本文报道一种简便且可高度重复的骨髓培养系统,它可使小鼠无细胞毒活性的前体细胞产生具有细胞毒活性的NK细胞。作者用4小时~(51)Cr释放实验测定NK活 Much progress has been made in the study of NK cell regulation, but there is still a lack of understanding of its origin and its regulation at the level of stem cells. NK cells are known to originate from bone marrow cells and are highly dependent on bone marrow function. This article reports a simple and highly reproducible bone marrow culture system that produces cytotoxic NK cells in mouse cytotoxic free progenitor cells. The authors used 4 hours ~ (51) Cr release assay to determine NK activity