【摘 要】
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Cognitive impairment caused by chemotherapy, referred to as “chemobrain,” is observed in approximately 70％ of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for
【机 构】
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Department of Pharmacology and Toxicology,College of Pharmacy,Qassim University,Buraidah,Kingdom of
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Cognitive impairment caused by chemotherapy, referred to as “chemobrain,” is observed in approximately 70％ of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported to reduce the effects of chemobrain. Recently, several studies have examined the effect of metformin in rescuing chemobrain. This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action.
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