Multiple pollutants including pathogenic microorganism contaminations and emerging organic contaminations (EOCs) have shown a growing threat to the environment, especially the natural waters.However, the control and removal of pathogenic microorganism contaminations and EOCs have been greatly limited since limited knowledge of their environmental behaviors. Thus, a novel and efficient photocatalyst Ag2O/BiOBr heterojunction was synthesized and used for removal of multiple pollutants including Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), tetracycline and acetaminophen under visible light. The results showed that there were valid electron transfer pathways between BiOBr and Ag2O, the main electron transfer direction was the BiOBr to Ag2O. Photo-generated electrons were stored in Ag2O and thus separation efficiency between holes and photo-generated electrons was obviously enhanced. Active oxygen species were highly produced and eventually end up with the high efficiency of removal of multiple pollutants. For Ag2O/BiOBr with Ag2O content at 3％ (the best performance) under visible light, log decrease of E. coliwas 7.16 (removal efficiencywas 100％) in 120 min, log decrease of S. aureus was 7.23 (removal efficiency was 100％) in 160 min, C/C0 of tetracyclinewas 0.06 in 180 min, C/C0 of acetaminophenwas 0.17 in 180 min. This work could provide a promising candidate in the actual contaminated natural waters for cleaning multiple pollutants.