论文部分内容阅读
以携带ｖ－ｆｅｓ癌基因的Ｓｎｙｄｅｒ－Ｔｈｅｉｌｅｎ猫科肉瘤病毒（ＦｅｌｉｎｅｓａｒｃｏｍａｖｉｒｕｓｏｆＳｎｙｄｅｒ－Ｔｈｅｉｌｅｎｓｔｒａｉｎ，ＳＴ－ＦｅＳＶ）感染免疫组幼鼠４７只。ＦＴＳ（血清胸腺因子）组幼鼠３０只，对照组幼鼠３０只。接种部位肉瘤发生率在免疫组、ＦＴＳ组、对照组分别为４０４％，６３３％和７６７％。免疫组无ｖ－ｆｅｓ基因产物Ｐ８５表达，ＦＴＳ组有１０例（１０／１３）肉瘤表达，对照组有３例（３／６）肉瘤表达。原位杂交结果表明免疫组仅见散在细胞有较弱ｖ－ｆｅｓ基因信号，ＰＴＳ与对照组多数细胞有较强基因信号。结果表明：宿主免疫状态可影响肿瘤的发生及性质。
Seventy-five immunized mice were infected with Snyder-Theilen feline sarcoma virus (Felinearcomavirus of Snyder-Theilenstrain, ST-FeSV) carrying the v-fes oncogene. Thirty rats in the FTS (serum thymocyte factor) group and 30 young rats in the control group. The incidence of sarcoma at the site of inoculation was 40.4%, 63. 3%, and 76.7% in the immunized group, the FTS group, and the control group, respectively. There was no expression of p85 in v-fes gene product in the immunized group, 10 cases (10/13) of sarcoma in the FTS group, and 3 cases (3/6) of sarcoma in the control group. The results of in situ hybridization showed that scattered cells had weaker v-fes gene signals in the immunized group, and PTS and most of the cells in the control group had stronger gene signals. The results showed that host immune status can affect the occurrence and nature of tumors.