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Objective: To determine the response to tamoxifen in a woman with hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonist drugs. Design: Case report. Setting: Academic fertility center. Patient(s): A young woman with persistent amenorrhea, symptomatic hypogonadotropic hypogonadism, and hyperprolactinemia. Intervention(s): Tamoxifen was administered in addition to bromocriptine. Main Outcome Measure(s): Measurements of follicle-stimulating hormone, estradiol, prolactin, and progesterone. Result(s): Recovery of gonadal-hypothalamic-pituitary axis. Conclusion(s): Tamoxifen can revert the effects of chronic hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonists.
Objective: To determine the response to tamoxifen in a woman with hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonist drugs. Design: Case report. Setting: Academic fertility center. Patient (s): A young woman with persistent amenorrhea, symptomatic hypogonadotropic hypogonadism, Main Outcome Measure (s): Measurements of follicle-stimulating hormone, estradiol, prolactin, and progesterone. Results (s): Recovery of gonadal-hypothalamic-pituitary axis Conclusion (s): Tamoxifen can revert the effects of chronic hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonists.