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细胞凋亡的抑制与恶性肿瘤的发生发展以及对化疗、放疗不敏感有密切关系。和ｂｃｌ -2家族一样 ,凋亡抑制蛋白 (ｉｎ ｈｉｂｉｔｏｒｏｆａｐｏｐｔｏｓｉｓ ,ＩＡＰ)也是抑制细胞凋亡的重要成分。迄今为止 ,已经鉴定出ＩＡＰ家族中的 5个同族体 (ｈｏｍｏｌｏｇｕｅ)。Ｓｕｒ
The inhibition of apoptosis is closely related to the occurrence and development of malignant tumors and the insensitivity to chemotherapy and radiotherapy. Like the bcl-2 family, in hibitor ofapoptosis (IAP) is also an important component of apoptosis inhibition. So far, five homologues have been identified in the IAP family. Sur