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目的:检测ILK、SIRT1和PTEN在子宫内膜样腺癌中的表达,关注三者在不同临床特征中的临床价值。方法:选择99例确诊为子宫内膜样腺癌并进行手术治疗的患者作为观察组,选择75例增生期子宫内膜组织作为对照组,应用免疫组化法检测两组ILK、SIRT1和PTEN的表达,分析ILK、SIRT1和PTEN在不同病理特征中的表达差别。结果:观察组中ILK、SIRT1表达的阳性率明显高于对照组(P<0.05),观察组中PTEN表达的阳性率明显低于对照组(P<0.05)。观察组中ILK、SIRT1和PTEN的表达与肿瘤的最大径、肌层浸润及是否累及宫颈管密切相关。线性相关分析显示,观察组中ILK和SIRT1的表达具有正相关性。结论:子宫内膜样腺癌中ILK、SIRT1高表达及PTEN低表达对肿瘤的进展起重要作用,ILK和SIRT1可能具有正向协同作用。联合检测ILK、SIRT1和PTEN的表达可能对判断肿瘤的生物学行为有重要价值。
Objective: To detect the expression of ILK, SIRT1 and PTEN in endometrioid adenocarcinoma and to investigate their clinical value in different clinical features. Methods: Ninety-nine patients with endometrioid adenocarcinoma who were diagnosed as endometrioid adenocarcinoma were selected as observation group and 75 cases of proliferative endometrium were selected as control group. Immunohistochemistry was used to detect the expression of ILK, SIRT1 and PTEN Expression, analysis of ILK, SIRT1 and PTEN differences in the expression of different pathological features. Results: The positive rate of ILK and SIRT1 expression in the observation group was significantly higher than that in the control group (P <0.05). The positive rate of PTEN expression in the observation group was significantly lower than that in the control group (P <0.05). The expression of ILK, SIRT1 and PTEN in the observation group was closely related to the maximum diameter of the tumor, myometrial invasion and the involvement of the cervical canal. Linear correlation analysis showed that there was a positive correlation between ILK and SIRT1 expression in observation group. Conclusion: The high expression of ILK and SIRT1 and the low expression of PTEN in endometrioid adenocarcinoma play important roles in tumor progression. ILK and SIRT1 may have positive synergistic effects. Joint detection of ILK, SIRT1 and PTEN expression may determine the biological behavior of the tumor has important value.