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毒代动力学研究是将药动学的原理和研究方法应用于毒性剂量下药物体内过程的一门科学,研究毒性剂量下药物的吸收、分布、代谢、排泄特点,通过毒代动力学参数AUC、Cmax、tmax、t1/2等反映药物全身暴露情况,进而探讨药物毒性发生和发展的规律。常用的分析方法包括HPLC、LC-MS、LC-MS-MS、GC、GS-MS和CE等。毒代动力学研究的临床应用研究资料较少,涉及药物主要包括精神和神经系统药物,少数为心血管系统药物、胰岛素和毒性中草药等。本综述对药代动力学在药物中毒临床解救中的应用情况进行了介绍。
Toxicokinetic study is the pharmacokinetic principles and research methods applied to toxic doses of drugs in vivo process of a science to study toxicological dose absorption, distribution, metabolism, excretion characteristics, through the toxicokinetic parameters AUC , Cmax, tmax, t1 / 2 reflect the whole body drug exposure, and then explore the occurrence and development of drug toxicity law. Common analytical methods include HPLC, LC-MS, LC-MS-MS, GC, GS-MS and CE. Toxicokinetic studies of clinical application of less research, involving drugs mainly include mental and nervous system drugs, a small number of cardiovascular system drugs, insulin and toxic herbs. This review describes the application of pharmacokinetics in clinical rescue of drug poisoning.