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目的:探讨低分子肝素对早发型子痫前期(PE)患者再次妊娠时妊娠结局的影响。方法:回顾分析2010年1月至2016年1月因早发型PE在郑州大学第一附属医院产科终止妊娠后再次妊娠时预防性应用低分子肝素的57例患者的临床资料,比较患者的两次妊娠结局。结果:再次妊娠时的妊娠时间、新生儿出生体重、新生儿存活率均大于前次妊娠,新生儿窒息发生率、胎儿生长受限发生率、严重并发症发生率均小于前次妊娠,差异有统计学意义(P<0.05);两次妊娠时的产时产后出血量比较,差异无统计学意义(P>0.05);再次妊娠时发病组的FIB、D-DT大于未发病组,差异有统计学意义(P<0.05)。结论:早发型PE患者再次妊娠时预防性应用低分子肝素,可降低PE的发病率及并发症的发生率,改善再次妊娠时围产儿的结局,不增加出血事件的风险。
Objective: To investigate the effect of low molecular weight heparin on the pregnancy outcome of preeclampsia (PE) patients with re-pregnancy. Methods: The clinical data of 57 patients with low molecular weight heparin prophylactically applied during the first trimester of pregnancy after termination of pregnancy in the obstetric department of the First Affiliated Hospital of Zhengzhou University from January 2010 to January 2016 were retrospectively analyzed. The patients were compared twice Pregnancy outcome. Results: Pregnancy time, neonatal birth weight and neonatal survival rate were greater than the previous pregnancy, the incidence of neonatal asphyxia, fetal growth restriction, the incidence of serious complications were less than the previous pregnancy, the difference was (P <0.05). There was no significant difference in the amount of postpartum hemorrhage between the two pregnancies (P> 0.05). The FIB and D-DT in the pregnant group were higher than those in the non-infected group Statistical significance (P <0.05). CONCLUSIONS: Premature pregnancy with low-molecular-weight heparin in preeclampsia PE patients may reduce the incidence of PE and the incidence of complications and improve the outcomes of perinatal infants during the second trimester of pregnancy without increasing the risk of bleeding.