该研究显示了重组的人体肿瘤坏死因子(TNF)结合超声加热(HT)的协同效果。采用的实验动物为小鼠(C57BL/6)。在它们的后腿植入肺癌细胞,使得8天后50只小鼠的肿瘤体积增长到0.4～0.7cm~3不等,9天后另50只小鼠的肿瘤体积在1.5一2.scm3之间。超声加热前30分钟在它们腹膜内用TNF,然后使用三个直径为’omm的超声换能器圆片同时加热三个肿瘤。所用超声的频率为 This study shows the synergistic effect of recombinant human tumor necrosis factor (TNF) combined with ultrasound heating (HT). The experimental animal used was mouse (C57BL/6). Lung cancer cells were implanted on their hind legs. After 8 days, the tumor volume of 50 mice increased to 0.4-0.7 cm-3, and after 9 days, the tumor volume of 50 mice ranged from 1.5-2.scm3. They were treated intraperitoneally with TNF 30 minutes prior to ultrasound heating, and then three tumors were heated simultaneously using three ultrasound transducer disks of diameter ’omm. The frequency of ultrasound used is