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观察飞龙掌血（ Ｔａｄｄａｌｉａ ａｓｉａｔｉｃａ Ｌａｍ）水提物（飞龙一号， Ｆ０１）对正常动物心脏功能和血液动力学的影响。方法：正常家猫麻醉后开胸，在人工呼吸下观测用药前后动物左心室内压、左室舒张末期压、心室内压变化速率、动脉血压、心输出量和心率等各项参数的变化。结果：两种剂量（７３．５、 １２７ｍｇ／ｋｇ）的 Ｆ０１静脉注射后，显著降低 ＬＶＰ、ＴＰＶＲ、ＳＢＰ、ＤＢＰ、ＭＢＰ、ＬＶＷＩ、ＴＴＩ和 ｄｐ／ｄｔ_(ｍａｘ)（Ｐ＜０．０５或 Ｐ＜０．０１）；ＴＦＩ×ＨＲ、－ｄｐ／ｄｔ_(ｍａｘ)、ＣＯ、ＣＩ和 ＳＩ在使用 Ｆ０１ １２７ ｍｇ／ｋｇ后有显著性降低（Ｐ＜０．０５或Ｐ＜０．０１），但在使用小剂量Ｆ０１（７３．５ｍｇ／ｋｇ）后变化不显著（Ｐ＞０．０５）；ｔ－ｄｐ／ｄｔ_(ｍａｘ)和Ｖｃｅ－ＣＰＩＰ在用药后稍有下降（Ｐ＞０．０５）；ＬＶＥＤＰ和ＨＲ几乎无变化。结论：Ｆ０１除扩张外周血管降低心脏的后负荷外，对心脏有明显抑制作用，从而显著减少心肌作功和耗氧，可能是其抗心肌缺血的另一作用机制。
Observe the effects of Taddalia asiatica Lam aqueous extract (Flying Dragon 1, F01) on cardiac function and hemodynamics in normal animals. METHODS: Normal domestic cats were anesthetized and their chest opened. Under artificial respiration, changes in various parameters such as left ventricular pressure, left ventricular end diastolic pressure, intraventricular pressure, arterial blood pressure, cardiac output, and heart rate were observed. RESULTS: After two doses of F01 (73.5, 127 mg/kg) were injected intravenously, LVP, TPVR, SBP, DBP, MBP, LVWI, TTI and dp/dt_(max) were significantly reduced (P<0.05 or P). <0.01); TFI×HR, -dp/dt_(max), CO, CI and SI were significantly lower after F01 127 mg/kg (P<0.05 or P<0.01), but There was no significant change after using a small dose of F01 (73.5 mg/kg) (P>0.05); t-dp/dt_(max) and Vce-CPIP decreased slightly after administration (P>0.05); LVEDP and HR are almost unchanged. Conclusion: In addition to the expansion of the peripheral blood vessels, F01 has a significant inhibitory effect on the heart, which can significantly reduce myocardial work and oxygen consumption. It may be another mechanism of anti-myocardial ischemia.