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目的研究多根乌头不同部位提取物的急性毒性与抗炎镇痛活性。方法 ig给予小鼠不同浓度的多根乌头提取物,采用改进寇氏法计算小鼠的半数致死量(LD50);采用二甲苯致小鼠耳廓肿胀与乙酸致小鼠扭体模型来考察其抗炎镇痛活性。结果多根乌头的水、环己烷、乙酸乙酯与乙醇提取物对小鼠的LD50分别为1.04、0.65、0.38、1.48 g·kg-1;乙酸乙酯提取物对小鼠耳廓肿胀的抑制率为32.75%、扭体抑制率为66.67%,均为最大。结论多根乌头的乙酸乙酯提取物有较大的毒性,但其抗炎镇痛活性最强。
Objective To study the acute toxicity and anti-inflammatory and analgesic activity of extracts from different parts of aconite. Methods ig mice were given different concentrations of aconite extract, using improved Kovar method to calculate the half-lethal dose (LD50) in mice; using mouse xylene-induced ear swelling and acetic acid induced writhing model in mice to investigate Its anti-inflammatory and analgesic activity. Results The LD50 of mice with aconite water, cyclohexane, ethyl acetate and ethanol extract were 1.04,0.65,0.38,1.48 g · kg-1, respectively. Ethyl acetate extract had auricle swelling in mice Of the inhibition rate was 32.75%, writhing inhibition rate of 66.67%, are the largest. Conclusion The aconite with ethyl acetate extract is more toxic, but its anti-inflammatory and analgesic activity is the strongest.