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风湿性关节炎最常见症状为疼痛。在疼痛困扰时大多数患者寻求药物治疗。当慢性疼痛不能有效地控制时会改变患者的个性、生活方式和能力,会产生抑郁及影响睡眠。目前要解除这些病人的慢性疼痛仍有困难。许多患者采用催眠药来处理因疼痛所致失眠。本文分析风湿病患者应用笨二氮草类约(BDP)情况。风湿病患者127例,包括风湿性关节炎及关节强直性脊椎炎的炎症性患者106例(84%),骨关节炎的非炎症性患者21例(16%)。不用 BDP 组90例,男性33、女性57例,平均年龄61±1.37岁,超过60岁者51例(57%);夜间疼痛者31例(34%).白天疼痛者53例(59%)。采用 BDP 组37例,男性3例,女性34例;平均年龄65±1.42岁,超过60岁者28例(76%);夜间疼痛28例(76%),白天疼痛33例(89%)。用 BDP 平均年限为4.1年。女性用 BDP 类药明显多于男性(P<0.001)。用 BDP 者年龄明显高于不采用者(t=2.49,P<0.05)。采用非类固醇类抗炎药(NSAIDs)者非 BDP 组为88%,BDP组为60%(P<0.001)。采用麻醉剂可待因加丙氧芬者,非 BDP 组18%,BDP 组46%(P<0.01)。
The most common symptom of rheumatoid arthritis is pain. Most patients seek medical attention when pain is disturbed. When chronic pain can not be effectively controlled, it can change a patient’s personality, lifestyle, and ability to develop depression and affect sleep. It is still difficult to relieve chronic pain in these patients. Many patients use hypnotics to treat pain-induced insomnia. This article analyzes the application of stupid diazepines (BDP) in patients with rheumatism. A total of 127 patients with rheumatoid arthritis, including rheumatoid arthritis and ankylosing spondylitis inflammatory patients in 106 cases (84%), osteoarthritis non-inflammatory patients in 21 cases (16%). There were 90 cases in the BDP group, 33 cases in the male group, 57 cases in the female group, with an average age of 61 ± 1.37 years, 51 cases (57%) over 60 years old, 31 cases (34%) of nighttime pain, 53 cases . There were 37 cases in the BDP group, 3 males and 34 females. The average age was 65 ± 1.42 years old, 28 (76%) were over 60 years old. The nighttime pain was 28 (76%) and the daytime pain was 33 (89%). The average life span of BDP is 4.1 years. Women with BDP drugs were significantly more than men (P <0.001). Patients with BDP were significantly older than non-adoptees (t = 2.49, P <0.05). Non-steroidal anti-inflammatory drugs (NSAIDs) were 88% in the non-BDP group and 60% in the BDP group (P <0.001). With anesthetic codeine plus propofol, 18% in non-BDP group and 46% in BDP group (P <0.01).