用PCR-SSO方法研究云南西部彝族HLA朌QB1基因的多态性

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应用PCR-SSO基因分型技术,对我国云南西部地区3代内无血缘关系的76个彝族健康个体进行了HLA-DQB1位点的基因分型。结果显示,在DQB1的38个等位基因中,观察到13个等位基因。云南西部彝族表现为DQB10301(36.18%~36.84%)最常见。其他频率大于5%的等位基因还有DQB10502(10.53%~11.18%)、DQB10401(9.21%)、DQB10302 (8.55%~9.21%)、DQB10601(7.89%)、DQB105031(6.58%)、DQB103032(5.92%~6.58%)。和其他13个华人群体DQB1等位基因的频率比较分析表明,总体上,云南西部彝族和其他各华人群体间都存在很大的差异。显示其HLA等位基因频率分布的民族独特性。
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