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目的研究健康人伏立康唑(抗真菌药)血浆和唾液浓度的相关性。方法20名男性健康志愿者分别单剂量口服伏立康唑片200 mg,用液相色谱-串联质谱法测定伏立康唑血浆和唾液浓度,用DAS 2.0软件计算药代动力学参数,用SPSS 10.0比较2种浓度及药代动力学参数的相关性。结果伏立康唑血浆浓度(Cp)和唾液浓度(Cs)的相关性公式Cs=0.69Cp-35.96,γ=0.9710,血浆浓度和唾液浓度呈显著的正向相关关系(P<0.01),Cs/Cp为0.59±0.53。Cs和Cp的药代动力学参数t1/2Ka、t1/2、Tmax较为接近,无显著性差异(P>0.05)。结论可用唾液浓度代替血浆浓度进行伏立康唑的药物浓度监测和人体药代动力学研究。
Objective To study the correlation between plasma and saliva concentrations of voriconazole (antifungal drug) in healthy volunteers. Methods Twenty healthy volunteers were given a single oral dose of voriconazole 200 mg. The plasma and saliva concentrations of voriconazole were determined by liquid chromatography-tandem mass spectrometry. The pharmacokinetic parameters were calculated by DAS 2.0 software. The concentrations of Correlation of pharmacokinetic parameters. Results The correlation between voriconazole plasma concentration and saliva concentration was Cs = 0.69Cp-35.96, γ = 0.9710, the plasma concentration and saliva concentration had a significant positive correlation (P <0.01), Cs / Cp was 0.59 ± 0.53. The pharmacokinetic parameters t1 / 2Ka, t1 / 2 and Tmax of Cs and Cp were close, with no significant difference (P> 0.05). Conclusion Saliva concentration can be used instead of plasma concentration of voriconazole drug concentration monitoring and human pharmacokinetic studies.