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目的:比较米非司酮配伍米索前列醇与利凡诺在终止妊娠中临床效果与安全性。方法:选取自愿终止妊娠者86例,随机分成观察组和对照组,每组各43例。观察组使用米非司酮配伍米索前列醇;对照组予以利凡诺行羊膜腔内穿刺注射。观察两组的引产过程、引产效果及可能出现的副作用。结果:观察组用药后宫缩发动时间、产程均短于对照组(P<0.01);观察组与对照组引产成功率分别为93.02%、86.05%,无统计学差异(P>0.05);但观察组24h内引产成功率显著高于对照组,而对照组24~48 h、48 h后引产成功率显著高于观察组(P<0.01)。观察组胎膜残留、产后2h内出血量、药物热、胃肠道反应、腹痛的发生率均低于对照组(P<0.05或P<0.01)。结论:米非司酮联合米索前列醇终止中期妊娠具有方法简单、宫缩发动快、产程短、损伤小、出血少等优点,优于利凡诺羊膜腔内穿刺注射。
Objective: To compare the clinical efficacy and safety of mifepristone with misoprostol and rivanol in terminating pregnancy. Methods: Eighty-six patients who voluntarily terminated pregnancy were randomly divided into observation group and control group, with 43 cases in each group. The observation group was treated with mifepristone and misoprostol, while the control group was treated with rivanolian amniocentesis. The induction of labor, induction of labor and possible side effects were observed in both groups. Results: The duration of uterine contractions and the duration of labor in the observation group were shorter than those in the control group (P <0.01). The successful rates of induction of labor in the observation group and the control group were 93.02% and 86.05%, respectively. There was no significant difference (P> 0.05) In the observation group, the success rate of induction of labor was significantly higher than that of the control group in 24 hours, but the success rate of induction of labor in the control group was significantly higher than that of the observation group after 24-48 hours and 48 hours (P <0.01). Observation group residual fetal membranes, bleeding within 2h postpartum, drug fever, gastrointestinal reactions, abdominal pain were lower than the control group (P <0.05 or P <0.01). Conclusion: The combination of mifepristone and misoprostol has the advantages of simple method, fast onset of contractions, short labor, less injury and less bleeding, which is superior to rivanol injection in the amniotic cavity.