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为了评价继发性肺动脉高压(PH)患者用硝苯吡啶(N)后的血液动力学变化,对7例晚期COPD、3例肺纤维化(隐源性纤维性肺泡炎、晚期结节病、风湿性肺疾病各1例)并发肺动脉高压患者进行了研究。方法治疗前24h停用除β_2激动剂外的所有药物,3h前停吸氧及β_2激动剂。用Swan-Ganz三腔热稀释管插管,监测肺动脉压。用热稀释法测心输出量。在心率、血压、呼吸稳定情况下开始试验,持续监测平均动脉压(MAP)。基础变量值包括:平均右房压
In order to evaluate the hemodynamic changes after nifedipine (N) in patients with secondary pulmonary hypertension (PH), 7 patients with advanced COPD, 3 with pulmonary fibrosis (cryptogenic alveolar inflammation, advanced sarcoidosis, 1 case of rheumatic lung disease) were studied in patients with pulmonary hypertension. Methods All drugs except β 2 agonist were stopped before treatment 24h and oxygen and β 2 agonists were stopped 3h before treatment. Pulmonary arterial pressure was monitored using a Swan-Ganz three-chamber thermodilution tube. Measure the cardiac output with thermal dilution. The heart rate, blood pressure, respiratory stability began trial, continuous monitoring of mean arterial pressure (MAP). The basic variable values include: mean right atrial pressure