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β_2-微球蛋白(β_2-MG)与肾脏关系密切。近年对其在血、尿中含量的检测已较多地应用于临床。本文报道73例肾脏病人血、尿β_2-MG的测定结果,并探讨其临床意义。1 对象与方法1.1 对象 经临床及实验室检查确诊的73例肾脏病患者中,急性肾小球肾炎38例,慢性肾炎20例,尿毒症15例。男性33例,女性40例。年龄14～61岁,平均32.5岁。另以健康成人20例作正常对照。1.2 方法 急性肾炎分别于急性期、恢复期检测,慢性肾炎、尿毒症于入院时检测。其值与正常对照组比较,统计处理采用t检验。所有病人均检测血Cr,内生肌酐清除率(Ccr),并与血β_2-MG值作相关性检验。检测药盒由上海放射免疫研究所提供,采用双抗-PEG法。
β_2-microglobulin (β_2-MG) and the kidney are closely related. In recent years, its blood, urine testing has been more used in clinical. This article reports 73 cases of kidney disease blood, urine β_2-MG results, and explore its clinical significance. 1 objects and methods 1.1 objects clinically and laboratory confirmed 73 cases of patients with kidney disease, acute glomerulonephritis in 38 cases, 20 cases of chronic nephritis, uremia in 15 cases. 33 males and 40 females. Aged 14 to 61 years old, with an average of 32.5 years old. Another 20 healthy adults as a normal control. 1.2 Methods Acute nephritis were detected in the acute phase, convalescence, chronic nephritis, uremia detected at admission. Its value compared with the normal control group, statistical analysis using t test. Blood Cr, endogenous creatinine clearance (Ccr) were detected in all the patients, and the correlation with blood β_2-MG was tested. Test kit provided by the Shanghai Institute of Radioimmunology, using double anti-PEG method.