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It has been found that the potassium channel dysfunction of the membrane of airway smooth muscle cells (ASMCs) is closely associated with proliferation of ASMCs.~1 Preliminary research has demonstrated that pinacidil, an ATP sensitive potassium channel (K_(ATP)) opener, could play a remarkable role in the prevention and treatment of antigen induced bronchial asthma in guinea pigs.~2 (This study)was designed to investigate further the role and molecular mechanism of the proliferation of ASMCs: a chief pathological change of the nonacute phase of bronchial asthmatic episodes.
It has been discovered that the potassium channel dysfunction of the membrane of airway smooth muscle cells (ASMCs) is closely associated with proliferation of ASMCs. ~ 1 Preliminary research has demonstrated that pinacidil, an ATP sensitive potassium channel (K_ (ATP) opener, could play a remarkable role in the prevention and treatment of antigen induced bronchial asthma in guinea pigs. ~ 2 (This study) was designed to investigate further the role and molecular mechanism of the proliferation of ASMCs: a chief pathological change of the nonacute phase of bronchial asthmatic episodes.