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在白血病患者中多次检测到由点突变引起的ras家族原癌基因的活化,说明ras家族原癌基因的活化与多步骤致白血病作用有关。用DNA转染的方法转化因子依赖性髓样细胞,是研究目的基因功能的有效方法。曾有人报告活化的ras基因不引起
Multiple activation of the ras family of oncogenes caused by point mutations was detected in leukemia patients, indicating that the activation of the ras family of oncogenes is associated with multiple-step leukemia. Transfection of factor-dependent myeloid cells with DNA transfection is an effective way to study the function of the gene of interest. It has been reported that the activated ras gene is not caused