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目的:研究柯萨奇-腺病毒受体(CAR)在宫颈癌组织中的表达及意义,探讨其在宫颈癌形成和演进过程中的作用。方法:采用免疫组织化学方法检测10例正常宫颈组织、72例宫颈原位癌以及浸润癌组织中CAR表达水平,分析评价其临床意义,预测CAR表达与宫颈癌发生发展的关系。结果:与正常宫颈组织相比,宫颈癌组织普遍存在CAR表达下调(P<0.001),CAR的表达与宫颈癌的临床分期、组织学分级和淋巴结转移无关(P>0.05);CAR的表达在宫颈癌组织病理类型中的差异有统计学意义,即宫颈腺癌组织中CAR表达明显高于鳞癌(P<0.05)。结论:在绝大多数宫颈癌组织中存在CAR表达下调;CAR表达变化与宫颈癌灶的组织类型相关,可以作为宫颈癌发生、发展及临床转移的重要生物学指标,其具体作用机制值得进一步研究。
Objective: To investigate the expression and significance of coxsackie-adenovirus receptor (CAR) in cervical cancer and to explore its role in the development and progression of cervical cancer. Methods: The expression of CAR was detected by immunohistochemistry in 10 cases of normal cervical tissue, 72 cases of cervical carcinoma in situ and invasive carcinoma, and its clinical significance was analyzed. The relationship between CAR expression and the occurrence and development of cervical cancer was predicted. Results: Compared with normal cervical tissue, CAR expression was significantly down-regulated in cervical cancer (P <0.001). The expression of CAR was not associated with clinical stage, histological grade and lymph node metastasis (P> 0.05) The difference of histopathological types in cervical cancer was statistically significant, that is, the expression of CAR in cervical adenocarcinoma was significantly higher than that in squamous cell carcinoma (P <0.05). CONCLUSION: CAR expression is down-regulated in most cervical cancer tissues. The changes of CAR expression correlate with the tissue type of cervical cancer, which may serve as an important biological indicator for the occurrence, development and clinical metastasis of cervical cancer. The specific mechanism of action is worth further study .