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甲状腺激素(thyroid hormone,T3)对于生长、发育、分化和维持新陈代谢平衡具有重要作用。甲状腺激素受体(thyroid hormone receptor,TR)通过转录调控调节这些生物活动。TR来源于2种基因,THRA和THRB,分别位于不同的染色体。初级转录产物的选择性剪接产生了TR的4种亚型,α1,β1,β2和β3。这些亚型具有发育调控性和组织依赖性。TR通过结合T3靶基因启动子区的TR元件对转录作用进行调控[1]。鉴于TR具有重要的生物学作
Thyroid hormone (T3) plays an important role in growth, development, differentiation and maintenance of metabolic balance. Thyroid hormone receptor (TR) regulates these biological activities through transcriptional regulation. TR originates from two genes, THRA and THRB, located on different chromosomes. Alternative splicing of primary transcripts results in 4 subtypes of TR, α1, β1, β2 and β3. These subtypes are developmentally regulated and tissue-dependent. TR regulates transcription by binding to the TR element in the promoter region of the T3 target gene [1]. Given the important biology of TR