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目的探讨Cx43在皮肤BCC中的表达及其意义。方法用免疫组化方法(S-P法)和原位分子杂交法检测18例BCC、20例SCC中Cx43、Cx43mRNA的表达。利用计算机图像分析系统采集、分析图像,并对数据进行统计学处理。结果Cx43、Cx43mRNA在BCC中呈阳性或弱阳性表达,在SCC中呈阴性或弱阳性表达,两者在BCC中的表达水平均明显高于SCC(“p<0.01”)。结论Cx43基因及其蛋白的高表达可能与BCC生长缓慢及极少转移的生物学特性有关。
Objective To investigate the expression of Cx43 in skin BCC and its significance. Methods The expressions of Cx43 and Cx43 mRNA in 18 cases of BCC and 20 cases of SCC were detected by immunohistochemistry (S-P method) and in situ hybridization. The use of computer image analysis system to collect, analyze the image, and the data for statistical processing. Results Cx43 and Cx43 mRNA were positive or weakly positive in BCC and negative or weakly positive in SCC. The expression levels of both Cx43 and Cx43 in BCC were significantly higher than those in SCC ( “p <0.01 ”). Conclusion The high expression of Cx43 gene and its protein may be related to the biological characteristics of slow and minimal metastasis of BCC.