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本文研究１２名健康志愿者连续多次口服β阻滞剂阿替洛尔后，外周血淋巴细胞β受体密度（Ｂｍａｘ）和血浆６－酮－前列腺素Ｆ（６－ｋｅｔｏ－ＰＧＦ）／血栓素（ＴＸＢ２）的动态变化，观察β阻滞剂对正常生理状态下受体密度的调节和血浆血管活性物质的影响。结果显示，服药后第３、５、７天，Ｂｍａｘ均值较基础值分别增加４５、５６和６７％，６－ｋｅｔｏ－ＰＧＦ（较基础值有增加趋势，均值分别增加８５、１０６和６９％。这一结果提示，β阻滞剂可能具有除拮抗交感神经以外的其它有益作用。
In this study, 12 healthy volunteers after continuous oral administration of beta blockers atenolol, peripheral blood lymphocyte beta receptor density (Bmax) and plasma 6-keto-prostaglandin F (6-keto-PGF) / thromboxane (TXB2), and observe the effects of β-blockers on the regulation of receptor density and plasma vasoactive substances under normal physiological conditions. The results showed that on the 3rd, 5th and 7th day after treatment, the mean Bmax increased by 45, 56 and 67% respectively compared with the baseline values. The 6-keto-PGF increased with the increase of the baseline values, with the mean increase of 85, 106 and 69% respectively. This result suggests that beta blockers may have other beneficial effects in addition to antagonizing the sympathetic nerve.